Description

2,5-Anhydro-6-Azido-4,6-Dideoxy-4-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-1-(Dimethyl Acetal)-L-Mannose is a sophisticated nucleoside analogue building block, a key intermediate in the synthesis of novel antiviral and anticancer agents. Its value lies in its unique structural features, including the anhydro bridge, azido group, and protected mannose moiety, which enable precise modifications for drug discovery and development. This high-purity intermediate is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on creating next-generation therapeutic nucleosides and nucleotides.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor for antimetabolite drugs designed to disrupt cancer cell DNA/RNA synthesis.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation & Probe Development: The reactive azido group allows for click chemistry applications to create labeled probes for biochemical studies.
• Carbohydrate Chemistry: A specialized substrate for studying modified sugar chemistry and enzymatic transformations.

Basic Information

Product Name	2,5-Anhydro-6-Azido-4,6-Dideoxy-4-(3,4-Dihydro-5-Methyl-2,4-Dioxo-1(2H)-Pyrimidinyl)-1-(Dimethyl Acetal)-L-Mannose
CAS No.	900513-65-7
Molecular Formula	C14H20N6O7
Molecular Weight	384.35 g/mol
Synonyms	1-(Dimethyl Acetal)-2,5-Anhydro-6-Azido-4,6-Dideoxy-4-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-L-Mannose; 4-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-2,5-Anhydro-6-Azido-4,6-Dideoxy-1-O-(Dimethyl Acetal)-L-Mannose; 6-Azido-2,5-Anhydro-4,6-Dideoxy-4-(5-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-1-O-(Dimethyl Acetal)-L-Mannose; L-Mannose Derivative CAS 900513-65-7; Nucleoside Sugar Intermediate; Azido-Modified Nucleoside Precursor
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Our quality system includes identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled as a strong oxidizer; keep away from heat, sparks, and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.