Description

(R)-Methyl 2-Amino-5,8-Dimethoxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the development of active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, cardiovascular drugs, and other complex therapeutic molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Asymmetric Synthesis: Utilized in research and development for constructing molecules with high enantiomeric purity, leveraging its defined (R)-configuration.
• Medicinal Chemistry Research: Employed as a scaffold or precursor for structure-activity relationship (SAR) studies in drug discovery programs.
• Reference Standard: Used as an analytical standard for method development and quality control in pharmaceutical manufacturing processes.
• Process Chemistry Development: Applied in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) specializing in custom synthesis of advanced intermediates.

Basic Information

Product Name	(R)-Methyl 2-Amino-5,8-Dimethoxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylate
CAS No.	99907-83-2
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	(2R)-2-Amino-5,8-dimethoxy-3,4-dihydro-2H-naphthalene-2-carboxylic acid methyl ester; Methyl (2R)-2-amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate; (R)-2-Amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid methyl ester; (R)-Amino-dimethoxy-tetrahydronaphthalene carboxylate; (R)-ADTN-Carboxylate Methyl Ester; (R)-Methyl ADTN-2-carboxylate; (R)-5,8-Dimethoxy-2-aminotetralin-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-Amino-5,8-Dimethoxy-1,2,3,4-Tetrahydronaphthalene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.