Description

1,2-Cyclohexanediol, 1-(4-Methylbenzenesulfonate) CAS NO 99835-44-6 is a specialized organic intermediate featuring a cyclohexanediol core functionalized with a tosylate (p-toluenesulfonate) ester group. This molecular architecture makes it a valuable building block in synthetic organic chemistry, particularly for the controlled introduction of the diol moiety or for further functionalization via nucleophilic substitution of the sulfonate ester. It is primarily sought by research and development chemists and process engineers in the pharmaceutical and fine chemical industries. Its utility lies in enabling the synthesis of complex molecules, including potential active pharmaceutical ingredients (APIs) and advanced material precursors.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), leveraging the reactivity of the tosylate group.
• Fine Chemical Synthesis: Used as a protected or activated form of 1,2-cyclohexanediol for constructing complex organic molecules in agrochemical, fragrance, and specialty chemical research.
• Polymer Chemistry: Acts as a monomer or cross-linking agent precursor for the development of specialty polyesters, polycarbonates, or other polymers with tailored properties.
• Ligand and Catalyst Development: Provides a chiral or functional backbone for designing novel ligands used in asymmetric catalysis and metal complex formation.
• Academic and Industrial R&D: Employed in research laboratories for methodological studies and exploring new synthetic pathways due to its defined and versatile reactivity.

Basic Information

Product Name	1,2-Cyclohexanediol, 1-(4-Methylbenzenesulfonate)
CAS No.	99835-44-6
Molecular Formula	C13H18O4S
Molecular Weight	270.34 g/mol
Synonyms	1,2-Cyclohexanediol 1-tosylate; 1-Tosyloxy-1,2-cyclohexanediol; (1R,2S)-rel-1,2-Cyclohexanediol 1-(4-methylbenzenesulfonate); Cyclohexane-1,2-diol 1-tosylate; 4-Methylbenzenesulfonic acid 1,2-dihydroxycyclohexyl ester; 1,2-Cyclohexanediol mono-p-toluenesulfonate; p-Toluenesulfonic acid 1,2-cyclohexanediol ester
EINECS	Contact for details

Quality Control

Our 1,2-Cyclohexanediol, 1-(4-Methylbenzenesulfonate) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key specifications such as assay (HPLC), chiral purity (if applicable), and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.