Description

n-[(1S,2S)-1,2,3,4-Tetrahydro-1-Hydroxy-7-Methoxy-2-Naphthalenyl]-Chloroacetamide is a chiral, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its specific stereochemistry and functional groups, which make it a critical building block for creating complex, biologically active molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with defined three-dimensional configurations.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry Development: Used in the optimization and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Fine Chemical Synthesis: A building block for the production of specialty chemicals requiring high enantiomeric purity.

Basic Information

Product Name	n-[(1S,2S)-1,2,3,4-Tetrahydro-1-Hydroxy-7-Methoxy-2-Naphthalenyl]-Chloroacetamide
CAS No.	99833-89-3
Molecular Formula	C₁₃H₁₆ClNO₃
Molecular Weight	269.72 g/mol
Synonyms	(1S,2S)-N-(1-Hydroxy-7-methoxy-1,2,3,4-tetrahydro-2-naphthyl)chloroacetamide; (1S,2S)-1,2,3,4-Tetrahydro-1-hydroxy-7-methoxy-N-(chloroacetyl)-2-naphthalenamine; 2-Chloro-N-[(1S,2S)-1-hydroxy-7-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl]acetamide; Chiral Tetralin Chloroacetamide Derivative; (1S,2S)-THN Chloroacetamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.