Description

8-Azabicyclo[3.2.1]Octane-3-Carboxaldehyde, 8-Methyl-, Endo- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique bridged bicyclic structure. This compound is of significant commercial value as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research and development chemists and process scale-up teams in the global pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for innovative drug discovery and manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of tropane alkaloid derivatives and other neurologically active compounds.
• Drug Discovery & Development: Used in medicinal chemistry for constructing complex molecular scaffolds in preclinical research for new therapeutic agents.
• Asymmetric Synthesis: Serves as a versatile starting material or chiral template in catalytic asymmetric reactions to introduce stereochemical complexity.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value nitrogen-containing heterocycles.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological studies and the development of novel synthetic pathways.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octane-3-Carboxaldehyde, 8-Methyl-, Endo- (9Ci)
CAS No.	99658-61-4
Molecular Formula	C9H15NO
Molecular Weight	153.22 g/mol
Synonyms	8-Methyl-8-azabicyclo[3.2.1]octane-3-carboxaldehyde, endo-; endo-8-Methyl-8-azabicyclo[3.2.1]octane-3-carbaldehyde; 3-Formyl-8-methyl-8-azabicyclo[3.2.1]octane; Tropane-3-carboxaldehyde, 8-methyl-; 8-Methylnortropinone aldehyde; Nortropane-3-carboxaldehyde, N-methyl-; A key tropane aldehyde intermediate.
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]Octane-3-Carboxaldehyde, 8-Methyl-, Endo- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (endo-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.