Description

5-Hydroxybucindolol is a key pharmaceutical intermediate and metabolite of the β-blocker bucindolol. This compound matters for its critical role in drug metabolism studies, pharmacokinetic research, and the development of analytical reference standards. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) focused on cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of bucindolol and its metabolites in analytical methods.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in studies to understand the metabolic pathways, bioavailability, and clearance of bucindolol.
• Impurity Profiling: Employed as a known impurity or degradation product during the quality control and stability testing of bucindolol API.
• Biomedical Research: Utilized in preclinical and clinical research to investigate the pharmacological activity and safety profile of bucindolol metabolites.
• Method Development & Validation: Critical for developing and validating sensitive analytical techniques such as HPLC, LC-MS, and GC-MS in regulatory submissions.

Basic Information

Product Name	5-Hydroxybucindolol
CAS No.	99541-39-6
Molecular Formula	C22H28N2O3
Molecular Weight	368.47 g/mol
Synonyms	5-Hydroxybucindolol; 1-[2-[2-Hydroxy-3-[[2-(5-hydroxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]phenoxy]-3-isopropylaminopropan-2-ol; Bucindolol Metabolite; 5-OH-Bucindolol; UNII-5Q9K5QJ1VJ
EINECS	Contact for details

Quality Control

Our 5-Hydroxybucindolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR, MS), and residual solvent analysis to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.