Description

Guanosine, 2'-Deoxy-3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-(2-Methyl-1-Oxopropyl)- is a sophisticated, protected nucleoside derivative, specifically engineered for advanced synthetic chemistry applications. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks for oligonucleotide synthesis and pharmaceutical development. It is primarily utilized by biotechnology firms, pharmaceutical R&D laboratories, and fine chemical producers engaged in the creation of novel therapeutics, diagnostic probes, and biochemical tools.

Application

• Oligonucleotide Synthesis: Serves as a key protected intermediate in the solid-phase synthesis of DNA and RNA sequences, particularly for research and therapeutic antisense oligonucleotides.
• Pharmaceutical Intermediate: Used in the research and development of nucleoside-based antiviral and anticancer drugs, where specific chemical modifications are required.
• Biochemical Research: Acts as a substrate or precursor in enzymatic studies and for investigating nucleic acid metabolism and function.
• Probe Development: Employed in the synthesis of labeled nucleotides for use in diagnostic assays, fluorescence in situ hybridization (FISH), and other molecular biology techniques.
• Fine Chemical Synthesis: Functions as a specialized building block for the custom synthesis of complex nucleoside analogs and other high-value chemical entities.

Basic Information

Product Name	Guanosine, 2'-Deoxy-3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-(2-Methyl-1-Oxopropyl)-
CAS No.	99540-94-0
Molecular Formula	C20H33N5O5Si
Molecular Weight	451.60 g/mol
Synonyms	2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine; N-Isobutyryl-2'-deoxy-3'-O-(tert-butyldimethylsilyl)guanosine; N2-Isobutyryl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine; 3'-O-TBDMS-N2-isobutyryl-2'-deoxyguanosine; dG(ib)-3'-O-TBDMS; Protected 2'-Deoxyguanosine Derivative; TBDMS-dG(ib)
EINECS	Contact for details

Quality Control

Our production of this high-purity nucleoside derivative adheres to stringent quality protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support GMP-grade applications and research requiring the highest standards of material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.