Description

(S)-1,2,4-Butanetriol Trimesylate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the synthesis of nucleoside analogs and other active pharmaceutical ingredients (APIs), where stereochemical control is critical for biological activity. This compound is essential for research and production in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for antiviral and anticancer drug development programs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of nucleoside and nucleotide analogs used as antiviral and anticancer agents.
• Antiviral Drug Development: Key precursor for prodrugs and modified nucleosides targeting viral polymerases.
• Bioconjugation & Prodrug Synthesis: Utilized for attaching targeting moieties or modifying drug solubility and bioavailability through its reactive mesylate groups.
• Asymmetric Synthesis: Serves as a chiral scaffold or auxiliary in stereoselective organic synthesis for complex molecule construction.
• Polymer Chemistry: Potential monomer or cross-linking agent for creating functionalized, chiral polymers with specialized properties.
• Chemical Biology Research: Used in the development of molecular probes and tools to study enzyme mechanisms and cellular processes.

Basic Information

Product Name	(S)-1,2,4-Butanetriol Trimesylate
CAS No.	99520-81-7
Molecular Formula	C13H20O9S3
Molecular Weight	424.48 g/mol
Synonyms	(S)-1,2,4-Trihydroxybutane Trimesylate; (S)-1,2,4-Tri-O-methanesulfonylbutane-1,2,4-triol; (S)-Butane-1,2,4-triyl Trimethanesulfonate; (S)-1,2,4-Tris(methanesulfonyloxy)butane; L-1,2,4-Butanetriol Trimesylate; (2S)-1,2,4-Trihydroxybutane Trimethanesulfonate; (S)-BT Trimesylate; NSC 334543
EINECS	Contact for details

Quality Control

Our (S)-1,2,4-Butanetriol Trimesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D and cGMP starting material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.