Description

Benzamide, n-(2-Piperidinylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)-, (R)-, Monoacetate is a high-purity, chiral organic compound of significant interest in advanced pharmaceutical research and development. This molecule is valued for its specific stereochemistry and trifluoroethoxy substituents, which are critical for modulating biological activity and pharmacokinetic properties. It serves as a key chiral intermediate or building block for medicinal chemists and process development scientists working on novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the efficacy and selectivity of drug candidates.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the commercial manufacturing of chiral drugs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized as a substrate or reagent in catalytic asymmetric reactions to construct complex molecular architectures.

Basic Information

Product Name	Benzamide, n-(2-Piperidinylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)-, (R)-, Monoacetate
CAS No.	99495-94-0
Molecular Formula	C20H26F6N2O5
Molecular Weight	488.42 g/mol
Synonyms	(R)-N-[(2-Piperidinyl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate; (R)-2,5-Bis(2,2,2-trifluoroethoxy)-N-(piperidin-2-ylmethyl)benzamide acetate; UNII-1JX8404F0C; 1JX8404F0C; Benzamide, N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate; Acetic acid, compound with N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide (1:1)
EINECS	Contact for details

Quality Control

Our Benzamide, n-(2-Piperidinylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)-, (R)-, Monoacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.