Description

Benzamide, n-(2-Piperidinylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)-, (S)-, Monoacetate CAS NO 99495-93-9 is a high-purity, chiral organic compound featuring a benzamide core substituted with trifluoroethoxy and piperidinylmethyl groups. This molecule is of significant commercial interest as a key chiral intermediate or building block in advanced pharmaceutical synthesis. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

This specialized chiral intermediate is designed for high-value synthesis applications where precise stereochemistry is critical. Its primary uses include:

• Pharmaceutical Intermediate: Serving as a key chiral building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or specialty therapeutics.
• Agrochemical Synthesis: Utilized in the development of advanced, enantiomerically pure agrochemicals such as herbicides or insecticides, where the (S)-configuration may confer specific biological activity.
• Chemical Research & Development: Acting as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• Process Chemistry: Employed in route scouting and scale-up processes for the production of complex molecules requiring this specific chiral motif.

Basic Information

Product Name	Benzamide, n-(2-Piperidinylmethyl)-2,5-Bis(2,2,2-Trifluoroethoxy)-, (S)-, Monoacetate
CAS No.	99495-93-9
Molecular Formula	C20H26F6N2O5
Molecular Weight	488.43 g/mol
Synonyms	(S)-N-[(2-Piperidinyl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetate; (S)-2,5-Bis(2,2,2-trifluoroethoxy)-N-(piperidin-2-ylmethyl)benzamide acetate; UNII-9F8S6A6F4F; 99495-93-9; Benzamide, N-[(2S)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetate; Acetic acid, compound with N-[(2S)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide (1:1)
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.