Description

9-o-Daunosaminyl-4-Demethoxydaunorubicin is a semi-synthetic anthracycline derivative, representing a key intermediate in the development of advanced chemotherapeutic agents. This compound is of significant interest for its role in the synthesis and research of novel anticancer drugs, particularly those designed to overcome multidrug resistance and reduce cardiotoxicity. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of next-generation anthracycline-based chemotherapeutic agents.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate mechanisms of action, efficacy, and toxicity profiles.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at modifying the daunosamine sugar moiety to improve pharmacokinetics and therapeutic index.
• Biochemical Studies: Employed in studies exploring DNA intercalation, topoisomerase II inhibition, and the induction of apoptosis in cancer cell lines.
• Analytical Standard: Used for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	9-o-Daunosaminyl-4-Demethoxydaunorubicin
CAS No.	99457-12-2
Molecular Formula	C27H29NO9
Molecular Weight	511.52 g/mol
Synonyms	4-Demethoxy-9-O-daunosaminyldaunorubicin; 9-O-Daunosaminyl-4-demethoxydaunorubicin; 4-Demethoxy-9-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)daunomycinone; Daunorubicin, 9-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-4-demethoxy-; IDR (Idarubicin related intermediate); 4-Demethoxy-9-O-(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 9-o-Daunosaminyl-4-Demethoxydaunorubicin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.