Description

Desmethylterbinafine is a key pharmaceutical intermediate and metabolite of the antifungal agent terbinafine. This compound is of significant importance in the research, development, and quality control of antifungal medications. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions involved in the synthesis of active pharmaceutical ingredients (APIs) and the study of drug metabolism.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of the antifungal drug terbinafine and its analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and biological activity of terbinafine.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of terbinafine API during manufacturing.
• Biochemical Research: Used in in-vitro studies to investigate the mechanism of action of antifungal agents targeting squalene epoxidase.

Basic Information

Product Name	Desmethylterbinafine
CAS No.	99450-97-2
Molecular Formula	C₂₁H₂₅N
Molecular Weight	291.43 g/mol
Synonyms	(2E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine; N-Desmethyl Terbinafine; Terbinafine Impurity C; Terbinafine Metabolite; (E)-N-Methyl-N-((6,6-dimethylhept-2-en-4-yn-1-yl)methyl)naphthalen-1-amine; LY 248663
EINECS	Contact for details

Quality Control

Our Desmethylterbinafine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.