Description

Acetyloxymethyl (5R,6R)-3-(Carbamoyloxymethyl)-6-(1-Hydroxyethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate is a key pharmaceutical intermediate, specifically a protected derivative of a β-lactam antibiotic core structure. This compound is critical for the synthesis of advanced cephalosporin antibiotics, offering a versatile building block for medicinal chemistry research and development. It is essential for manufacturers and R&D laboratories in the pharmaceutical industry focused on developing new antibacterial agents and improving synthetic routes for existing drugs.

Application

• Pharmaceutical Intermediate: Primary use as a protected synthon in the multi-step synthesis of advanced cephalosporin antibiotics.
• Antibiotic Research & Development: Serves as a crucial building block for medicinal chemists exploring new β-lactam structures with improved efficacy and spectrum of activity.
• Process Chemistry: Used in the development and optimization of scalable manufacturing processes for final active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the preparation of novel, structurally modified β-lactam compounds for biological screening.
• Academic Research: Employed in university and institutional labs studying antibiotic mechanisms of action, resistance, and novel synthetic methodologies.

Basic Information

Product Name	Acetyloxymethyl (5R,6R)-3-(Carbamoyloxymethyl)-6-(1-Hydroxyethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate
CAS No.	99376-22-4
Molecular Formula	C14H18N2O8S
Molecular Weight	374.37 g/mol
Synonyms	(5R,6R)-6-[(1R)-1-Hydroxyethyl]-3-[(acetyloxy)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Carbamoylmethyl Ester; Acetyloxymethyl (5R,6R)-6-(1-Hydroxyethyl)-3-[(aminocarbonyloxy)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; Cephalosporin C Derivative; Protected Cephem Ester; 3-Acetoxymethyl-3-carbamoyloxymethyl-7β-(1-hydroxyethyl)ceph-3-em-4-carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Quality is assured through analytical methods including HPLC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our global customer base in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.