Description

Pyrrolidine, 1-(2-Fluoro-3-Hydroxy-4,4-Dimethyl-1-Oxopentyl)-, (R*,S*)- (9Ci) is a specialized chiral pyrrolidine derivative featuring a fluorinated hydroxy keto acid side chain. This compound is valued as a high-purity advanced pharmaceutical intermediate and a versatile chiral building block for complex organic synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients. The defined stereochemistry and functional groups make it a critical precursor for constructing molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates.
• Agrochemical Synthesis: Used as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Asymmetric Catalysis: Serves as a precursor or ligand for chiral catalysts used in stereoselective chemical transformations.
• Medicinal Chemistry Research: Employed in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetics & Bioactive Molecule Design: The pyrrolidine core is integral for designing protease inhibitors and other bioactive compounds.
• Fine Chemical Synthesis: Applied in custom synthesis and contract manufacturing of complex, high-value specialty chemicals.

Basic Information

Product Name	Pyrrolidine, 1-(2-Fluoro-3-Hydroxy-4,4-Dimethyl-1-Oxopentyl)-, (R*,S*)- (9Ci)
CAS No.	99343-21-2
Molecular Formula	C11H20FNO3
Molecular Weight	233.28 g/mol
Synonyms	1-(2-Fluoro-3-hydroxy-4,4-dimethyl-1-oxopentyl)pyrrolidine; (R*,S*)-1-(2-Fluoro-3-hydroxy-4,4-dimethyl-1-oxopentyl)pyrrolidine; 2-Fluoro-3-hydroxy-4,4-dimethyl-1-pyrrolidin-1-ylpentan-1-one; Fluorinated hydroxy keto pyrrolidine derivative; Chiral fluorinated pyrrolidine intermediate; 99343-21-2; (Rac)-1-[(2-Fluoro-3-hydroxy-4,4-dimethyl-1-oxopentyl)]pyrrolidine
EINECS	Contact for details

Quality Control

We supply this compound as a high-purity intermediate suitable for research and development. Our quality assurance process includes rigorous analytical testing to ensure batch-to-batch consistency and identity confirmation. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, chiral purity (where applicable), and impurity profiles as determined by HPLC, GC, NMR, and other relevant techniques. We adhere to cGMP principles for handling and documentation to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.