Description

m-Bromoacetyldistamycin is a synthetic derivative of the natural antibiotic distamycin A, modified with a bromoacetyl group at the meta position. This compound is a critical pharmaceutical intermediate and research tool, valued for its ability to act as a sequence-specific DNA minor groove binder and alkylating agent. It is primarily utilized by pharmaceutical R&D teams and academic research institutions engaged in the development of novel anticancer and antimicrobial therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced antitumor agents and sequence-specific DNA-targeting drugs.
• Biochemical Research: Used as a tool compound to study DNA-protein interactions, gene regulation, and the mechanisms of minor groove binders.
• Anticancer Drug Development: Serves as a core structure for developing novel chemotherapeutic agents with enhanced specificity and potency.
• Antimicrobial Research: Investigated for the design of new antibiotics targeting specific DNA sequences in pathogens.
• Molecular Biology Probes: Can be conjugated to fluorescent tags or other reporter molecules for diagnostic and research applications.

Basic Information

Product Name	m-Bromoacetyldistamycin
CAS No.	99328-13-9
Molecular Formula	C25H30BrN7O5
Molecular Weight	588.46 g/mol
Synonyms	3-Bromoacetyldistamycin A; m-Bromoacetyldistamycin A; Distamycin A, 3'-(bromoacetyl)-; 3'-(Bromoacetyl)distamycin A; NSC 351521; 1-Methyl-4-[3-[3-[3-[3-(2-bromoacetamido)propionamido]propionamido]propionamido]propyl]pyrrole-2-carboxamidine
EINECS	Contact for details

Quality Control

Our m-Bromoacetyldistamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and MS structural confirmation, and residual solvent testing to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.