Description

4'-Hydroxy Torsemide is a key pharmaceutical intermediate and metabolite of the loop diuretic agent Torsemide. This compound matters for its critical role in the research, development, and quality control of diuretic medications, ensuring efficacy and safety. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug synthesis, metabolite studies, and impurity profiling.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Torsemide and related diuretic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and excretion pathways of Torsemide.
• Impurity Standard: Serves as a known impurity standard for HPLC and other chromatographic assays to ensure drug purity and compliance with ICH guidelines.
• Biochemical Research: Utilized in studies investigating the mechanism of action of loop diuretics on sodium-potassium-chloride co-transporters.
• Custom Synthesis: A starting material for the custom synthesis of novel derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4'-Hydroxy Torsemide
CAS No.	99300-67-1
Molecular Formula	C16H20N4O4S
Molecular Weight	364.42 g/mol
Synonyms	1-[4-[(3-Methylphenyl)amino]pyridin-3-yl]sulfonyl-3-(hydroxymethyl)urea; 4'-OH Torsemide; Torsemide Impurity F (EP); Torsemide Metabolite; 3-[[[(4-Hydroxy-3-methylphenyl)amino]carbonyl]amino]-4-pyridinecarboxylic acid 1,1-dioxide derivative; UNII-5V5M1R4W5P
EINECS	Contact for details

Quality Control

Our 4'-Hydroxy Torsemide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.