Description

5-Methyl-D-Tryptophan is a non-proteinogenic, enantiomerically pure derivative of the essential amino acid tryptophan. This compound is of significant interest in pharmaceutical research and development, particularly as a chiral building block and a potential metabolic modulator. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, stereochemically defined compounds for advanced synthesis and biological studies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel therapeutic agents, including peptide-based drugs and enzyme inhibitors.
• Biochemical Research: Used as a standard or reagent in metabolic pathway studies, particularly those involving tryptophan metabolism and amino acid transport.
• Enzyme Substrate/Analogue: Acts as a substrate or inhibitor for enzymes like tryptophan hydroxylase or decarboxylase in mechanistic and inhibition studies.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) and to create peptides with enhanced stability or specific biological activity.
• Nutritional Science Research: Investigated for its potential effects on metabolic processes as a modified amino acid.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5-Methyl-D-Tryptophan
CAS No.	99295-79-1
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.25 g/mol
Synonyms	(R)-2-Amino-3-(5-methyl-1H-indol-3-yl)propanoic acid; D-5-Methyltryptophan; (R)-5-Methyltryptophan; 5-Methyl-D-Trp; 5-Me-D-Trp; (2R)-2-Amino-3-(5-methyl-1H-indol-3-yl)propanoic acid; 5-Methyl-(R)-tryptophan
EINECS	Contact for details

Quality Control

Our 5-Methyl-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.