Description

Carbamic Acid, [(1R,2R)-2-Hydroxy-1-(Hydroxymethyl)Propyl]-, 1,1- is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and stereochemically defined building block for constructing complex molecules with high biological relevance. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for antiviral, antibacterial, and enzyme inhibitor applications.
• Peptidomimetic Research: Used to introduce constrained, hydroxy-functionalized side chains into peptide backbones to modulate stability, bioavailability, and receptor binding affinity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective synthesis.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme mechanisms or protein-protein interactions due to its defined stereochemistry and functional groups.
• Custom Synthesis: Employed in contract research and manufacturing (CRAM) for the custom production of specialized fine chemicals and reference standards.

Basic Information

Product Name	Carbamic Acid, [(1R,2R)-2-Hydroxy-1-(Hydroxymethyl)Propyl]-, 1,1-
CAS No.	99216-67-8
Molecular Formula	C6H13NO4
Molecular Weight	163.17 g/mol
Synonyms	(1R,2R)-1-(Aminocarbonyl)-2-hydroxy-1-(hydroxymethyl)propane; (2R,3R)-3-Amino-2,4-dihydroxy-3-methylbutyramide; (1R,2R)-2-Hydroxy-1-(hydroxymethyl)propylcarbamic Acid; D-erythro-3-Amino-2,4-dihydroxy-3-methylbutyramide; A Chiral Isoxazolidine Precursor; A Chiral β-Amino Acid Derivative
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1R,2R)-2-Hydroxy-1-(Hydroxymethyl)Propyl]-, 1,1- adheres to strict in-process controls to ensure batch-to-batch consistency and high chiral purity. Each lot is fully characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.