Description

2-[[2-(3,4-Dihydro-2H-Chromen-2-Yl)-2-Hydroxyethyl]Amino]-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanol is a specialized chromane derivative of significant interest in advanced organic synthesis. This compound serves as a key chiral intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the discovery and production of cardiovascular and neurological therapeutics, where its unique fluorinated chromane structure is leveraged for biological activity.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates targeting cardiovascular and central nervous system (CNS) disorders.
• Chiral Synthesis: Used in asymmetric synthesis to introduce specific stereochemistry into complex molecules, essential for creating enantiomerically pure APIs.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Fine Chemical Production: Serves as a precursor for the manufacture of other high-value, fluorinated specialty chemicals.
• Contract Research & Development (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	2-[[2-(3,4-Dihydro-2H-Chromen-2-Yl)-2-Hydroxyethyl]Amino]-1-(6-Fluoro-3,4-Dihydro-2H-Chromen-2-Yl)Ethanol
CAS No.	99200-13-2
Molecular Formula	C22H26FNO4
Molecular Weight	387.45 g/mol
Synonyms	1-(6-Fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol; 2-[[2-(3,4-Dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethan-1-ol; 6-Fluoro-2-[[2-(3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]methyl]chroman; Chromane derivative CAS 99200-13-2; Fluorinated chromane ethanolamine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. All materials are subjected to rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.