Description

(S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Nitrophenoxy)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a 2-nitrophenoxy side chain. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and process chemistry teams for developing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and protease inhibitors.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-proteinogenic amino acid residues into peptide backbones to enhance metabolic stability and binding affinity.
• API Development: Serves as a building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeled peptides for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct stereogenic centers.

Basic Information

Product Name	(S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Nitrophenoxy)Propanoic Acid
CAS No.	99197-78-1
Molecular Formula	C₁₄H₁₈N₂O₇
Molecular Weight	326.30 g/mol
Synonyms	Boc-L-2-Nitrophenoxyalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(2-nitrophenoxy)propanoic acid; Boc-2-Nitrophenoxy-L-alanine; N-Boc-O-(2-nitrophenyl)-L-serine; N-(tert-Butoxycarbonyl)-3-(2-nitrophenoxy)-L-alanine; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-(2-nitrophenoxy)-; (S)-3-(2-Nitrophenoxy)-2-((tert-butoxycarbonyl)amino)propanoic acid
EINECS	Contact for details

Quality Control

Our (S)-2-((tert-Butoxycarbonyl)Amino)-3-(2-Nitrophenoxy)Propanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.