Description

Benzeneacetic Acid, α-(Acetylamino)-α-(Hydroxymethyl)- is a specialized organic compound featuring both acetamido and hydroxymethyl functional groups on the alpha carbon of a phenylacetic acid backbone. This unique structure makes it a valuable versatile chiral building block and intermediate for the synthesis of more complex molecules. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers engaged in developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for neurological and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators.
• Peptidomimetic Research: Serves as a constrained amino acid analog in the design of peptide-like molecules with enhanced metabolic stability.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Acts as a precursor for specialty chemicals used in dyes, flavors, and fragrances.
• Academic & Industrial Research: A valuable compound for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	Benzeneacetic Acid, α-(Acetylamino)-α-(Hydroxymethyl)-
CAS No.	99155-34-7
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	2-(Acetamido)-2-(hydroxymethyl)phenylacetic acid; N-Acetyl-α-(hydroxymethyl)phenylglycine; α-Acetamido-α-(hydroxymethyl)benzeneacetic acid; (αR/S)-2-(Acetylamino)-2-(hydroxymethyl)benzeneacetic acid; Acetamidohydroxymethylphenylacetic acid; N-Acetyl-2-(hydroxymethyl)-2-phenylglycine; (RS)-2-(Acetamido)-2-(hydroxymethyl)-2-phenylacetic acid; Phenylacetic acid derivative (Acetamido, Hydroxymethyl)
EINECS	Contact for details

Quality Control

Our production of Benzeneacetic Acid, α-(Acetylamino)-α-(Hydroxymethyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for critical applications. Each lot undergoes comprehensive analysis, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all relevant specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.