Description

(αr,3S)-3-[[(R)-4-[(R)-3-Amino-3-Carboxypropoxy]PhenylAcetyl]Amino]-α-(4-Hydroxyphenyl)-2-Oxo-1-Azetidineacetic Acid CAS NO 99124-80-8 is a complex, high-purity azetidinone derivative with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate or building block. Its intricate molecular architecture, featuring multiple chiral centers and functional groups, makes it invaluable for the synthesis of novel, targeted therapeutic agents. This compound is primarily sought by research institutions and pharmaceutical development teams working on next-generation antibiotics and enzyme inhibitors.

Application

• Key Intermediate in β-Lactam Antibiotic Research: Serves as a sophisticated precursor in the synthesis of novel penem and carbapenem analogs.
• Pharmaceutical Active Ingredient (API) Development: Used in the research and development of new chemical entities (NCEs) targeting bacterial infections.
• Enzyme Inhibition Studies: Employed in biochemical research as a potential inhibitor for serine-based enzymes due to its β-lactam core.
• Stereoselective Synthesis: Acts as a chiral template or building block for constructing complex molecules with specific three-dimensional configurations in medicinal chemistry.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes for the commercial production of specialized antibiotics.

Basic Information

Product Name	(αr,3S)-3-[[(R)-4-[(R)-3-Amino-3-Carboxypropoxy]PhenylAcetyl]Amino]-α-(4-Hydroxyphenyl)-2-Oxo-1-Azetidineacetic Acid
CAS No.	99124-80-8
Molecular Formula	C24H26N4O9
Molecular Weight	514.49 g/mol
Synonyms	(3S,4R)-3-[[(R)-2-[[4-[(R)-3-Amino-3-carboxypropoxy]phenyl]formamido]acetyl]amino]-4-(4-hydroxyphenyl)-2-oxoazetidine-1-acetic acid; (Ar,3S)-3-[[(R)-4-[(R)-3-Amino-3-carboxypropoxy]phenylacetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid; 1-Azetidineacetic acid, 3-[[2-[[4-[(3-amino-3-carboxypropoxy)phenyl]formamido]acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-, (3S,4R)-; Carbapenem intermediate; β-lactam intermediate; 99124-80-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our (αr,3S)-3-[[(R)-4-[(R)-3-Amino-3-Carboxypropoxy]PhenylAcetyl]Amino]-α-(4-Hydroxyphenyl)-2-Oxo-1-Azetidineacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.