Description

Carbamic Acid, n-[(1S,2R)-2,3-Dihydroxy-1-(Phenylmethyl)Propyl]-, 1,1-Dimethylethyl Ester is a chiral, protected amino alcohol derivative of significant interest in advanced organic synthesis. This compound matters as a crucial, high-purity building block for constructing complex pharmaceutical molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). Pharmaceutical R&D laboratories and fine chemical manufacturers need this specific stereoisomer to ensure the correct biological activity and stereochemical integrity of their final drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of protease inhibitor drugs, including HIV-1 protease inhibitors.
• Peptidomimetic Research: Serves as a core scaffold for designing and synthesizing peptide analogs and mimetics in medicinal chemistry programs.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective reactions to introduce the (1S,2R)-configured amino diol moiety.
• API Development: Critical for the preparation of advanced intermediates in the commercial production of specific Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Used in the synthesis of labeled compounds and molecular probes for studying enzyme mechanisms and binding interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Item	Detail
Product Name	Carbamic Acid, n-[(1S,2R)-2,3-Dihydroxy-1-(Phenylmethyl)Propyl]-, 1,1-Dimethylethyl Ester
CAS No.	99113-35-6
Molecular Formula	C15H23NO4
Molecular Weight	281.35 g/mol
Synonyms	(1S,2R)-1-(Benzyl)-2,3-dihydroxypropyl carbamic acid tert-butyl ester; tert-Butyl N-[(1S,2R)-1-benzyl-2,3-dihydroxypropyl]carbamate; (1S,2R)-1-Benzyl-2,3-dihydroxypropylcarbamic acid tert-butyl ester; (1S,2R)-Benzyl-dihydroxypropyl-BOC-amine; BOC-(1S,2R)-Amino Diol Benzyl Derivative; N-BOC-(1S,2R)-1-Benzyl-2,3-dihydroxypropylamine; (1S,2R)-Epoxy Alcohol BOC-Carbamate Derivative; SCHEMBL ID
EINECS	Contact for details

Quality Control

Our Carbamic Acid, n-[(1S,2R)-2,3-Dihydroxy-1-(Phenylmethyl)Propyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality systems suitable for pharmaceutical R&D and pilot-scale applications. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high stereochemical and chemical purity. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.