Description

Boc-D-Gln(Xan)-Oh is a protected amino acid derivative, specifically the xanthyl (Xan) protected form of Boc-D-glutamine. This compound is a crucial building block in the synthesis of complex peptides, particularly where orthogonal protection strategies are required to prevent unwanted side reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-glutamine into peptide chains, especially in Fmoc/t-Bu strategies.
• Pharmaceutical Research: Used in the research and development of peptide drugs, hormones, and enzyme inhibitors where specific stereochemistry and side-chain protection are critical.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and high-throughput screening of bioactive peptides.
• Bioconjugation: Can be used to create peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Academic Research: Employed in university and institutional labs for studying peptide structure, function, and synthesis methodologies.
• Process Development: Used in scaling up the synthesis of specific peptide sequences for clinical and commercial manufacturing.

Basic Information

Product Name	Boc-D-Gln(Xan)-Oh
CAS No.	99092-88-3
Molecular Formula	C₂₀H₂₈N₂O₆
Molecular Weight	392.45 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-δ-(9H-xanthen-9-yl)-D-glutamine; Boc-D-glutamine(Xan)-OH; (2R)-5-[(9H-Xanthen-9-yl)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid; tert-Butyloxycarbonyl-D-glutamine(xanthyl); Boc-D-Gln(Xan)-OH; Boc-D-Glutamine(Xan)-OH; N-δ-Xanthyl-N-α-Boc-D-glutamine
EINECS	Contact for details

Quality Control

Our Boc-D-Gln(Xan)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.