Description

1-o-T-Butyldimethylsilyl 2-Azido-2-Deoxy-D-glucose is a key protected carbohydrate derivative, specifically designed for advanced synthetic chemistry applications. This compound is crucial for researchers and manufacturers requiring precise, stable intermediates in the synthesis of complex bioactive molecules. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel glycoconjugates, antiviral agents, and metabolic probes.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of nucleoside analogs and other antiviral or anticancer drug candidates.
• Glycoconjugate Synthesis: Used in the preparation of modified sugars for the study of carbohydrate-protein interactions and vaccine development.
• Metabolic Labeling: Acts as a precursor for "click chemistry" compatible probes to study cellular glycosylation processes and metabolic pathways.
• Chemical Biology Research: Enables the site-specific introduction of azide functional groups into complex biomolecules for subsequent bioconjugation.
• Oligosaccharide Assembly: Provides a protected, reactive glycosyl donor/acceptor for the stepwise construction of complex carbohydrate structures.
• Radiopharmaceutical Precursor: Potential use in the synthesis of radiolabeled compounds for Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	1-o-T-Butyldimethylsilyl 2-Azido-2-Deoxy-D-glucose
CAS No.	99049-65-7
Molecular Formula	C₁₂H₂₃N₃O₅Si
Molecular Weight	317.42 g/mol
Synonyms	2-Azido-2-deoxy-1-O-(tert-butyldimethylsilyl)-D-glucose; 1-O-TBDMS-2-azido-2-deoxy-D-glucose; 2-Azido-1-O-(tert-butyldimethylsilyl)-2-deoxy-D-glucopyranose; 2-Azido-2-deoxy-D-glucose 1-O-TBDMS ether; TBDMS-2-azido-2-deoxyglucose; 2-Azido-1-O-[(1,1-dimethylethyl)dimethylsilyl]-2-deoxy-D-glucopyranose; 2-Azido-2-desoxy-1-O-(tert-butyldimethylsilyl)-D-glucose
EINECS	Contact for details

Quality Control

Our 1-o-T-Butyldimethylsilyl 2-Azido-2-Deoxy-D-glucose is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The material is easily oxidized; therefore, containers should be purged with inert gas before resealing after each use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.