Description

n-Despropyl Pergolide 6-Carbonitrile is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound is a key structural analog in the synthesis pathway of dopaminergic agents and other complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics targeting neurological and endocrine systems.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex drug molecules, particularly dopaminergic agonists and related analogs.
• Neurological Research: Used as a reference standard or precursor in academic and industrial research focused on Parkinson's disease and other movement disorders.
• API Development: Serves as a key intermediate in the research, process development, and scale-up manufacturing of new chemical entities (NCEs).
• Metabolite Studies: Employed in the synthesis of labeled or unlabeled metabolites for pharmacokinetic and pharmacodynamic studies.
• Process Chemistry: Utilized in route scouting and optimization for the efficient commercial production of target pharmaceuticals.

Basic Information

Product Name	n-Despropyl Pergolide 6-Carbonitrile
CAS No.	98988-34-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pergolide 6-Carbonitrile, Despropyl Derivative; 8β-[(Methylthio)methyl]-6-propylergoline-6-carbonitrile; 6-Cyano-8β-[(methylthio)methyl]-6-propylergoline; 6-Cyano-6-propyl-8β-[(methylthio)methyl]ergoline; Pergolide 6-CN Intermediate; LY-127809 Related Compound
EINECS	Contact for details

Quality Control

Our n-Despropyl Pergolide 6-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The material should be handled under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.