Description

n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Arginine is a sophisticated, orthogonally protected derivative of the amino acid L-arginine, designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical selectivity, allowing for the precise and sequential assembly of complex peptides, particularly those containing multiple arginine residues, by enabling the controlled deprotection of specific functional groups. Pharmaceutical researchers, biotechnology firms, and fine chemical manufacturers need this high-purity building block for the development of therapeutic peptides, diagnostic agents, and biochemical tools where synthetic precision is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/tBu strategy, enabling the controlled incorporation of arginine into peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting cardiovascular diseases, metabolic disorders, and cancer.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides, affinity tags, and molecular probes used in biochemical and diagnostic assays.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Academic and Industrial Research: Essential reagent for studying protein-protein interactions, enzyme kinetics, and signal transduction pathways.
• GMP Manufacturing: Suitable for use in cGMP environments for the production of clinical trial materials and approved peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Arginine
CAS No.	98930-01-9
Molecular Formula	C₃₂H₃₈N₄O₇S
Molecular Weight	622.73 g/mol
Synonyms	Fmoc-Arg(Mtr)-OH; Nα-Fmoc-Nω-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-arginine; Fmoc-L-arginine(Mtr)-OH; Fmoc-Arg(Mtr)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-[4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-L-arginine; L-Arginine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]-; Fmoc-Arg(Mtr)-OH (Peptide Grade); Fmoc-L-Arginine(Mtr)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-N'-(4-Methoxy-2,3,6-Trimethylbenzenesulfonyl)-L-Arginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.