Description

Threo-n-Boc-D-Phenylalanine Epoxide is a high-purity, protected amino acid derivative of significant value in advanced organic synthesis. This chiral building block is essential for the controlled introduction of the phenylalanine moiety with an epoxide functional handle, enabling precise stereochemical outcomes. It is primarily utilized by researchers and process chemists in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of protease inhibitors, kinase inhibitors, and other targeted therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified phenylalanine residues, creating peptides with enhanced stability or biological activity.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and activity-based probes to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed in stereoselective ring-opening reactions of the epoxide to generate β-hydroxy-α-amino acids and other valuable chiral compounds.
• Library Synthesis: A valuable building block for generating diverse compound libraries in medicinal chemistry for high-throughput screening.
• Academic Research: Used in methodological studies and total synthesis projects within university and institutional laboratories.

Basic Information

Product Name	Threo-n-Boc-D-Phenylalanine Epoxide
CAS No.	98818-35-0
Molecular Formula	C₁₄H₁₇NO₅
Molecular Weight	279.29 g/mol
Synonyms	(2R,3S)-1-[(tert-Butoxycarbonyl)amino]-3-phenyl-1,2-epoxy-3-propane; tert-Butyl (2R,3S)-2,3-epoxy-3-phenylpropylcarbamate; (2R,3S)-N-Boc-3-phenylglycidamide; Boc-D-Phe-epoxide (threo); D-Threo-N-Boc-phenylalanine epoxide; (R,S)-Boc-phenylalanine epoxide (specific isomer); N-(tert-Butoxycarbonyl)-D-threo-3-phenylglycidamine
EINECS	Contact for details

Quality Control

Our Threo-n-Boc-D-Phenylalanine Epoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere (nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.