Description

Pyrrolidine, 1-(3,5-Dimethoxy-4-(2-(Dimethylamino)Ethoxy)Benzoyl)-, Et Hanedioate (1:1) is a high-purity, non-racemic pharmaceutical intermediate with a complex molecular architecture designed for targeted synthesis. This compound matters for its role as a critical building block in the development of advanced active pharmaceutical ingredients (APIs), particularly those requiring specific stereochemistry and functional group compatibility. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, where reliable quality and consistent supply are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially in central nervous system (CNS) and oncology research.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists exploring structure-activity relationships (SAR) and novel pharmacophores.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations due to its embedded pyrrolidine and amine functionalities.

Basic Information

Product Name	Pyrrolidine, 1-(3,5-Dimethoxy-4-(2-(Dimethylamino)Ethoxy)Benzoyl)-, Et Hanedioate (1:1)
CAS No.	98795-93-8
Molecular Formula	C20H30N2O7 • C4H4O4
Molecular Weight	534.55 g/mol
Synonyms	1-[3,5-Dimethoxy-4-[2-(dimethylamino)ethoxy]benzoyl]pyrrolidine Fumarate (1:1); Fumaric acid compound with 1-[3,5-dimethoxy-4-[2-(dimethylamino)ethoxy]benzoyl]pyrrolidine (1:1); (S)-1-(3,5-Dimethoxy-4-(2-(dimethylamino)ethoxy)benzoyl)pyrrolidine fumarate; L-741,626 fumarate; L741626 fumarate; Benzamide, N-[(3S)-1-pyrrolidinyl]-3,5-dimethoxy-4-[2-(dimethylamino)ethoxy]-, (2E)-2-butenedioate (1:1)
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(3,5-Dimethoxy-4-(2-(Dimethylamino)Ethoxy)Benzoyl)-, Et Hanedioate (1:1) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure compliance with stringent in-house specifications for pharmaceutical R&D use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.