Description

trans-(6-Amino-Cyclohex-3-Enyl)-Methanol is a chiral amino alcohol building block featuring a cyclohexene ring, an amino group, and a hydroxymethyl substituent in a specific trans configuration. This unique structure makes it a valuable intermediate for the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing novel drug candidates, such as enzyme inhibitors or receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs, antiviral agents, and other therapeutic compounds.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in asymmetric catalysis and synthesis to introduce stereochemical complexity into target molecules.
• Ligand and Catalyst Development: Used in the preparation of novel chiral ligands for metal-catalyzed reactions or organocatalysts.
• Peptidomimetics and Bioisosteres: The amino alcohol moiety is integral for creating peptide mimics and bioisosteric replacements in medicinal chemistry programs.
• Agrochemical Research: Potential intermediate in the development of new, more selective herbicides or pesticides.
• Academic and Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies and novel compound library generation.

Basic Information

Product Name	trans-(6-Amino-Cyclohex-3-Enyl)-Methanol
CAS No.	98769-57-4
Molecular Formula	C7H13NO
Molecular Weight	127.18 g/mol
Synonyms	(1R,4S)-4-(Aminomethyl)cyclohex-2-en-1-ol; (1R,4S)-4-(Aminomethyl)-2-cyclohexen-1-ol; trans-4-(Aminomethyl)cyclohex-2-en-1-ol; (1R,4S)-rel-4-(Aminomethyl)-2-cyclohexen-1-ol; (1R,4S)-4-(Aminomethyl)-1,2,3,4-tetrahydro-1-naphthol (incorrect but sometimes listed); 2-Cyclohexen-1-ol, 4-(aminomethyl)-, (1R,4S)-rel-; Amino alcohol intermediate 98769-57-4.
EINECS	Contact for details

Quality Control

Our trans-(6-Amino-Cyclohex-3-Enyl)-Methanol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.