Description

(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane is a high-value chiral epoxide building block, specifically engineered for the synthesis of complex pharmaceutical intermediates and fine chemicals. Its core value lies in the precise stereochemistry and the presence of a Boc-protected amine, which provides critical orthogonality in multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing peptide mimetics, protease inhibitors, and other active pharmaceutical ingredients (APIs) requiring defined stereocenters.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of HIV protease inhibitors and other antiviral agents.
• Peptidomimetic Chemistry: Used in constructing non-peptide scaffolds that mimic the structure and function of natural peptides.
• Asymmetric Synthesis: Serves as a starting material for nucleophilic ring-opening reactions to introduce amino alcohol functionalities with high enantiomeric purity.
• API Development: Critical for the research and scale-up of novel Active Pharmaceutical Ingredients (APIs) targeting cardiovascular and neurological diseases.
• Custom Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: A valuable reagent in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane
CAS No.	98737-29-2
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	(2S,3S)-3-[(tert-Butoxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; (2S,3S)-1,2-Epoxy-3-[(tert-butoxycarbonyl)amino]-4-phenylbutane; (2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane; tert-Butyl ((2S,3S)-1,2-epoxy-4-phenylbutan-3-yl)carbamate; (S,S)-Boc-Aminoepoxyphenylbutane; Boc-Amino Phenylbutane Oxide; Chiral Boc-Protected Amino Epoxide
EINECS	Contact for details

Quality Control

Our (2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard identity/purity assays. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.