Description

Trandolapril Benzyl Ester is a key pharmaceutical intermediate in the synthesis of the active pharmaceutical ingredient (API) Trandolapril. This compound matters for its critical role in the production chain of cardiovascular medications, specifically angiotensin-converting enzyme (ACE) inhibitors. Pharmaceutical manufacturers and advanced R&D facilities require this high-purity intermediate to ensure the efficacy and safety of the final drug product.

Application

• Primary Intermediate for the synthesis of the antihypertensive API Trandolapril.
• Research & Development of novel ACE inhibitor derivatives and prodrug formulations.
• Process Chemistry in scale-up and optimization of Trandolapril manufacturing routes.
• Reference Standard for analytical method development and quality control in pharmaceutical labs.
• Contract Manufacturing for companies specializing in cardiovascular drug production.

Basic Information

Product Name	Trandolapril Benzyl Ester
CAS No.	98677-37-3
Molecular Formula	C27H34N2O5
Molecular Weight	466.57 g/mol
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid benzyl ester; Trandolaprilat Benzyl Ester; Benzyl (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]octahydro-1H-indole-2-carboxylate; Trandolapril Intermediate; Trandolapril Benzyl Ester Intermediate
EINECS	Contact for details

Quality Control

Our Trandolapril Benzyl Ester is manufactured under strict quality management systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.