Description

S-(1,1,2,2,3,3-Hexafluoropropyl)-L-Cysteine is a specialized fluorinated cysteine derivative, a key building block in advanced pharmaceutical and agrochemical research. Its core value lies in introducing a highly lipophilic and electron-withdrawing hexafluoropropyl group, which can dramatically alter the metabolic stability, bioavailability, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in medicinal chemistry, particularly those developing novel protease inhibitors, enzyme modulators, and other bioactive compounds where precise stereochemistry and fluorine incorporation are critical.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and enzyme-targeted therapies.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) by incorporating a fluorinated side chain to modulate potency, selectivity, and pharmacokinetic properties.
• Agrochemical Development: Serves as a building block for creating advanced, fluorine-containing active ingredients with enhanced efficacy and environmental profile.
• Bioconjugation & Probe Synthesis: Utilized in the development of chemical probes and affinity labels for studying biological systems and enzyme mechanisms.
• Peptidomimetics: Incorporated into peptide analogs to increase metabolic stability and membrane permeability.

Basic Information

Product Name	S-(1,1,2,2,3,3-Hexafluoropropyl)-L-Cysteine
CAS No.	98640-41-6
Molecular Formula	C6H7F6NO2S
Molecular Weight	271.18 g/mol
Synonyms	L-Cysteine, S-(1,1,2,2,3,3-hexafluoropropyl)-; (2R)-2-Amino-3-[(1,1,2,2,3,3-hexafluoropropyl)sulfanyl]propanoic acid; S-(Hexafluoropropyl)-L-cysteine; S-(Perfluoropropyl)-L-cysteine; 98640-41-6; Fluorinated L-cysteine derivative
EINECS	Contact for details

Quality Control

Our S-(1,1,2,2,3,3-Hexafluoropropyl)-L-Cysteine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.