Description

3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid tert-butyl ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily sought after by research institutions and manufacturers in the global pharmaceutical and biotechnology sectors for drug discovery and process development programs.

Application

• Key Intermediate in API Synthesis: A crucial precursor in the multi-step synthesis of complex benzazepine-based pharmaceutical compounds.
• Drug Discovery & Medicinal Chemistry: Used in research laboratories for the design, synthesis, and screening of new chemical entities with potential biological activity.
• Process Development & Scale-Up: Employed in the optimization and pilot-scale production of candidate drugs, bridging the gap between research and commercial manufacturing.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid tert-butyl ester
CAS No.	98626-45-0
Molecular Formula	C₁₆H₂₂N₂O₃
Molecular Weight	290.36 g/mol
Synonyms	tert-Butyl 3-amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-acetate; 1H-1-Benzazepine-1-acetic acid, 3-amino-2,3,4,5-tetrahydro-2-oxo-, 1,1-dimethylethyl ester; 3-Amino-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-acetic acid tert-butyl ester; (3-Amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic acid tert-butyl ester; BOC-Aminobenzazepine intermediate; tert-Butyl (3-amino-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate
EINECS	Contact for details

Quality Control

Our 3-Amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid tert-butyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.