Description

n-(tert-Butoxycarbonyl)-L-Serine β-Lactone is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block, enabling the controlled introduction of serine moieties into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key intermediate for the solid-phase and solution-phase synthesis of serine-containing peptides, protecting the hydroxyl group during coupling reactions.
• Pharmaceutical Intermediates: Used in the research and production of potential therapeutic agents, including enzyme inhibitors and receptor antagonists.
• Prodrug Development: Employed in creating prodrug forms of serine-based compounds to improve bioavailability and pharmacokinetic profiles.
• Bioconjugation Chemistry: Acts as a reactive handle for linking peptides or other molecules to carriers, labels, or solid supports.
• Chemical Biology Probes: Utilized in the synthesis of specialized probes for studying biological processes and protein functions.
• Custom Fine Chemical Manufacturing: Serves as a starting material for the bespoke synthesis of complex, high-value organic molecules for clients.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-L-Serine β-Lactone
CAS No.	98541-64-1
Molecular Formula	C8H13NO4
Molecular Weight	187.19 g/mol
Synonyms	Boc-Serine-β-lactone; (S)-4-((tert-Butoxycarbonyl)amino)-2-oxetanone; Boc-L-Ser-β-lactone; (3S)-3-[(tert-Butoxycarbonyl)amino]oxetan-2-one; N-Boc-L-serine β-lactone; tert-Butyl (S)-2-oxooxetane-3-ylcarbamate; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, β-lactone
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-L-Serine β-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.