Description

[(1R,2S)-2-(Hydroxymethyl)Cyclobutyl]Methyl Acetate is a high-purity, chiral cyclobutane derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in its defined stereochemistry and functional group arrangement, enabling the precise construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals where stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where biological activity is highly dependent on molecular configuration.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and Industrial R&D: A valuable tool for methodological development in organic chemistry, particularly in ring-strain chemistry and stereoselective transformations.

Basic Information

Product Name	[(1R,2S)-2-(Hydroxymethyl)Cyclobutyl]Methyl Acetate
CAS No.	98516-06-4
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	(1R,2S)-2-(Acetoxymethyl)cyclobutylmethanol; (1R,2S)-rel-2-(Hydroxymethyl)cyclobutanemethanol acetate; Acetic acid [(1R,2S)-2-(hydroxymethyl)cyclobutyl]methyl ester; Cyclobutanemethanol, 2-(hydroxymethyl)-, acetate, (1R,2S)-rel-; (1R,2S)-2-(Acetoxymethyl)cyclobutane-1-methanol
EINECS	Contact for details

Quality Control

Our production of [(1R,2S)-2-(Hydroxymethyl)Cyclobutyl]Methyl Acetate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, and NMR to confirm identity, stereochemical purity (enantiomeric excess), and chemical assay. Certificates of Analysis (COA) documenting all critical quality attributes are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage under an inert atmosphere (e.g., nitrogen or argon), please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.