Description

(6R-Trans)-7-Amino-3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monohydrochloride is a high-purity pharmaceutical intermediate, specifically a cephalosporin derivative, that serves as a critical building block in advanced antibiotic synthesis. Its value lies in enabling the production of potent, broad-spectrum antibiotics, making it essential for ensuring a reliable supply chain for active pharmaceutical ingredient (API) manufacturers. This compound is primarily needed by research institutions, pharmaceutical development labs, and large-scale API producers focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced-generation cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating novel antibiotic compounds with improved efficacy.
• Antibiotic Research: Serves as a standard or reference material in microbiological and pharmacological studies.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for commercial-scale antibiotic production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) specializing in sterile and non-sterile antibiotic production.

Basic Information

Item	Details
Product Name	(6R-Trans)-7-Amino-3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monohydrochloride
CAS No.	98493-37-9
Molecular Formula	C12H15N5O3S3 • HCl
Molecular Weight	424.93 g/mol
Synonyms	7-ACA Thiadiazole Derivative; Cephalosporin C-3' Thiadiazolyl Thioether Hydrochloride; (6R,7R)-7-Amino-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride; 7-ATMH Hydrochloride; Cefotiam Intermediate; Antibiotic Intermediate 98493-37-9; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our (6R-Trans)-7-Amino-3-[[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, identification by IR and NMR, and tests for related substances and residual solvents to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.