Description

n-(Azetidin-3-Yl)-2,2,2-Trifluoroacetamide is a high-purity, advanced pharmaceutical intermediate featuring a reactive azetidine ring and a trifluoroacetamide moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique azetidine scaffold and fluorine substitution.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Development: The reactive amine group enables its use in creating chemical probes and bioconjugates for biochemical assays.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals and custom synthesis projects for the life sciences industry.

Basic Information

Product Name	n-(Azetidin-3-Yl)-2,2,2-Trifluoroacetamide
CAS No.	98448-79-4
Molecular Formula	C5H7F3N2O
Molecular Weight	168.12 g/mol
Synonyms	2,2,2-Trifluoro-N-(azetidin-3-yl)acetamide; 3-Aminoazetidine Trifluoroacetamide; 1-(2,2,2-Trifluoroacetyl)azetidin-3-amine; Azetidin-3-amine, N-(trifluoroacetyl)-; Trifluoroacetamide, N-(3-azetidinyl)-; 98448-79-4; 3-Trifluoroacetamidoazetidine
EINECS	Contact for details

Quality Control

Our n-(Azetidin-3-Yl)-2,2,2-Trifluoroacetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.