Description

S-(-)-Dihydrolipoic Acid is the biologically active enantiomer of dihydrolipoic acid, a key reduced form of the essential cofactor α-lipoic acid. This high-purity chiral compound is critical for research and development in advanced pharmaceutical and nutraceutical applications where stereospecific activity is required. It is primarily sought by manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and high-end dietary supplement sectors for its role in studying and developing antioxidant and metabolic therapies.

Application

• Pharmaceutical Intermediate: Used in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) targeting metabolic and neurological disorders.
• Biochemical Research: Serves as a critical reagent and standard in studies of mitochondrial function, antioxidant regeneration cycles (e.g., the glutathione and thioredoxin systems), and redox signaling pathways.
• Nutraceutical Formulations: Incorporated into advanced dietary supplements where the specific S-enantiomer is required for targeted biological efficacy and clinical research.
• Cosmeceutical Actives: Employed in premium skincare formulations for its potent antioxidant properties, helping to protect skin cells from oxidative stress.
• Cell Culture & Diagnostics: Used in specialized cell culture media and diagnostic assay kits as a redox modulator and protective agent.

Basic Information

Product Name	S-(-)-Dihydrolipoic Acid
CAS No.	98441-85-1
Molecular Formula	C8H16O2S2
Molecular Weight	208.34 g/mol
Synonyms	(R)-Dihydrolipoic Acid; (R)-6,8-Dimercaptooctanoic Acid; (R)-DHLA; R-Dihydrolipoate; (R)-1,2-Dithiolane-3-pentanoic Acid, Reduced; (R)-Thioctic Acid, Reduced; 6,8-Bis(sulfanyl)octanoic Acid, (6R)-; S-(-)-6,8-Dimercaptooctanoic Acid
EINECS	Contact for details

Quality Control

Our S-(-)-Dihydrolipoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets stringent specifications for research and cGMP-guided applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated area separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S-(-)-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.