Description

7β-[(Z)-2-(2-Aminothiazol-4-Yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-Acetoxymethyl-3-Cephem-4-Carboxylic Acid tert-Butyl Ester is a key advanced pharmaceutical intermediate in the synthesis of third-generation cephalosporin antibiotics. This compound is critical for ensuring the structural integrity and bioactivity of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and R&D organizations engaged in the development and production of potent, broad-spectrum antibacterial agents.

Application

• Critical Intermediate for Cephalosporin API Synthesis: Serves as a core building block in the production of advanced cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of novel β-lactam antibiotic candidates.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production from laboratory to commercial batch sizes.
• Generic Drug Manufacturing: Essential for manufacturers producing generic versions of third-generation cephalosporin drugs.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs specializing in high-potency active pharmaceutical ingredient (HPAPI) synthesis.
• Reference Standard Preparation: Used to prepare analytical standards for quality control and regulatory testing of final drug products.

Basic Information

Item	Details
Product Name	7β-[(Z)-2-(2-Aminothiazol-4-Yl)-2-(1-Carboxy-1-Methylethoxyimino)Acetamido]-3-Acetoxymethyl-3-Cephem-4-Carboxylic Acid tert-Butyl Ester
CAS No.	98382-95-7
Molecular Formula	C23H27N5O8S2
Molecular Weight	565.62 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester; 7-ACA tert-butyl ester derivative; Cephalosporin C-7 side chain intermediate; tert-Butyl 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(acetoxymethyl)-3-cephem-4-carboxylate; ATCA tert-butyl ester; GCE intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive battery of analytical tests including HPLC for purity and related substances, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or nitrogen blanket to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.