Description

Protected Imipenem is a crucial pharmaceutical intermediate, specifically a protected derivative of the potent carbapenem antibiotic, Imipenem. This compound is essential for the controlled synthesis and research of β-lactam antibiotics, ensuring the integrity of the sensitive β-lactam ring during chemical manipulations. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and academic research institutions focused on developing novel antibacterial agents and studying antibiotic resistance mechanisms.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key intermediate in the multi-step synthesis of the antibiotic Imipenem.
• Pharmaceutical Research & Development: Used in the discovery and development of new carbapenem and β-lactam antibiotic analogs.
• Process Chemistry & Scale-Up: Employed in optimizing manufacturing routes for Imipenem and related compounds.
• Biochemical Research: Serves as a tool compound for studying the biosynthesis, mechanism of action, and resistance profiles of β-lactam antibiotics.
• Reference Standard: Can be used as a chromatographic reference standard in quality control laboratories for impurity profiling.

Basic Information

Product Name	Protected Imipenem
CAS No.	98367-45-4
Molecular Formula	C12H17N3O4S • (C6H5CH2OCO)2O (Typical protecting group)
Molecular Weight	Contact for details
Synonyms	(5R,6S)-3-[[2-(Formimidoylamino)ethyl]thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Diphenylmethyl Ester; Imipenem Diphenylmethyl Ester; Imipenem DPM Ester; (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Diphenylmethyl Ester; N-Formimidoyl Thienamycin Diphenylmethyl Ester
EINECS	Contact for details

Quality Control

Our Protected Imipenem is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.