Description

3-Thiovitamin D3 is a synthetic analog of vitamin D, distinguished by the substitution of an oxygen atom with sulfur at the 3-position. This structural modification is of significant interest in pharmaceutical research for exploring novel biological pathways and developing potential therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the study of vitamin D receptor (VDR) modulation, metabolic bone diseases, and cancer research. The compound, identified by CAS NO 98353-78-7, offers a valuable tool for probing structure-activity relationships in medicinal chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel vitamin D analogs.
• Biochemical Research: Used to investigate the binding affinity and activation mechanisms of the Vitamin D Receptor (VDR) with sulfur-modified ligands.
• Metabolic Disease Studies: Applied in preclinical research targeting disorders related to calcium homeostasis and bone metabolism.
• Oncology Research: Explored for its potential effects on cell differentiation, proliferation, and apoptosis in various cancer cell lines.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic chemistry and steroid biochemistry.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in related compound analysis.

Basic Information

Product Name	3-Thiovitamin D3
CAS No.	98353-78-7
Molecular Formula	C27H44OS
Molecular Weight	416.71 g/mol
Synonyms	(5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-thiol; 3-Thia-1,25-dihydroxyvitamin D3; 3-Thiavitamin D3; 3-Thio-1α,25-dihydroxycholecalciferol; Vitamin D3 3-thiol analog; 3-Sulfanylvitamin D3; 98353-78-7
EINECS	Contact for details

Quality Control

Our 3-Thiovitamin D3 is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.