Description

Ethyl 1-Cyclopropyl-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise molecular structure. It is essential for R&D laboratories and manufacturing facilities focused on developing and producing next-generation antimicrobial agents.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A vital precursor in the synthesis of potent antibacterial agents like ciprofloxacin, levofloxacin, and other 6,7-difluoroquinolone derivatives.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel antimicrobial compounds.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in scaled-up production processes under GMP conditions for commercial antibiotic production.
• Chemical Synthesis Studies: Serves as a model compound in organic chemistry research exploring quinolone ring formation and fluorination reactions.
• Contract Manufacturing & Custom Synthesis: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	Ethyl 1-Cyclopropyl-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	98349-25-8
Molecular Formula	C15H13F2NO3
Molecular Weight	293.27 g/mol
Synonyms	1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; Ethyl 1-Cyclopropyl-6,7-difluoro-4-oxoquinoline-3-carboxylate; 6,7-Difluoro-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; Quinolone-3-carboxylic Acid Ester Derivative; Fluoroquinolone Intermediate E-6,7-F; CP-6,7-DFQ Ethyl Ester; 98349-25-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our Ethyl 1-Cyclopropyl-6,7-Difluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.