Description

L-Cysteine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is a protected derivative of the essential amino acid L-cysteine, specifically designed for advanced organic synthesis. This compound is crucial for researchers and manufacturers requiring precise control over cysteine's reactive thiol group during complex peptide and protein coupling reactions. It is primarily utilized in the pharmaceutical industry for the development of peptide-based therapeutics and in biochemical research for protein engineering and modification.

Application

• Peptide Synthesis: A key building block in solid-phase and solution-phase peptide synthesis, protecting the cysteine side chain from unwanted reactions.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the production of complex peptide drugs, including hormones, enzyme inhibitors, and antiviral agents.
• Bioconjugation: Used in the site-specific modification of proteins and antibodies for drug delivery systems, diagnostics, and biophysical studies.
• Chemical Biology Research: Enables the study of protein structure, function, and folding by allowing controlled introduction of cysteine residues or labels.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) and tert-butyl ester groups provide orthogonal protection, compatible with Fmoc-based peptide synthesis protocols.

Basic Information

Product Name	L-Cysteine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester
CAS No.	98330-15-5
Molecular Formula	C12H23NO4S
Molecular Weight	277.38 g/mol
Synonyms	Boc-Cys-OtBu; N-Boc-S-trityl-L-cysteine tert-butyl ester; N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine tert-butyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid tert-butyl ester; L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-Cys(Trt)-OtBu; Boc-L-cysteine(Trt)-OtBu; tert-Butyl N-(tert-butoxycarbonyl)-S-trityl-L-cysteinate
EINECS	Contact for details

Quality Control

Our L-Cysteine, n-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific results for purity, identity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.