Description

(2S)-4-Methyl-2-{[(Prop-2-En-1-Yloxy)Carbonyl]Amino}Pentanoic Acid is a chiral, non-natural amino acid derivative featuring a reactive allyloxycarbonyl (Alloc) protecting group on the amine functionality. This compound is a critical building block in advanced organic synthesis, offering precise stereochemical control and orthogonal deprotection capabilities. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel peptides, proteomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and bioactive molecules.
• Peptide Chemistry: Serves as an Alloc-protected leucine analog for solid-phase and solution-phase peptide synthesis (SPPS), enabling selective deprotection under mild, palladium-catalyzed conditions.
• Protease Inhibitor Development: Used in the design and construction of peptide-based enzyme inhibitors targeting specific proteolytic pathways.
• Chemical Biology & Bioconjugation: Acts as a versatile handle for introducing functional groups into peptides and proteins for labeling, cross-linking, or structural modification studies.
• Material Science: A potential monomer for creating specialized polymers with tailored biodegradability or bio-interactive properties.
• Academic & Industrial R&D: Employed in methodological research for developing new synthetic routes and catalytic processes in asymmetric synthesis.

Basic Information

Product Name	(2S)-4-Methyl-2-{[(Prop-2-En-1-Yloxy)Carbonyl]Amino}Pentanoic Acid
CAS No.	98204-51-4
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	N-Alloc-L-leucine; (S)-2-((Allyloxycarbonyl)amino)-4-methylpentanoic acid; N-[(Allyloxy)carbonyl]-L-leucine; Alloc-L-Leucine; L-Leucine, N-[(2-propen-1-yloxy)carbonyl]-; N-Carboxy-L-leucine allyl ester; 2-[[(Prop-2-en-1-yloxy)carbonyl]amino]-4-methylpentanoic acid (S)-form
EINECS	Contact for details

Quality Control

Our production of (2S)-4-Methyl-2-{[(Prop-2-En-1-Yloxy)Carbonyl]Amino}Pentanoic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.