Description

3-Isopropyl 5-Methyl 4-(2,3-Dichlorophenyl)-2-(Hydroxymethyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate CAS NO 98192-80-4 is a high-purity dihydropyridine derivative, a key structural motif in medicinal chemistry. This compound is valued for its role as a sophisticated pharmaceutical intermediate and a versatile research chemical in the development of novel therapeutic agents. It is primarily sought by R&D teams and production chemists in the pharmaceutical and fine chemical sectors for synthesizing advanced molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential calcium channel blockers and other cardiovascular drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Academic & Institutional Research: Employed in biochemical and pharmacological studies to investigate ion channel modulation and cellular signaling pathways.
• Process Development: Utilized in scaling up and optimizing synthetic routes for complex dihydropyridine-based active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the tailored synthesis of specialized derivatives for proprietary research and development.

Basic Information

Product Name	3-Isopropyl 5-Methyl 4-(2,3-Dichlorophenyl)-2-(Hydroxymethyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate
CAS No.	98192-80-4
Molecular Formula	C21H23Cl2NO5
Molecular Weight	440.32 g/mol
Synonyms	4-(2,3-Dichlorophenyl)-2-(hydroxymethyl)-3-(1-methylethyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester; 3-Isopropyl 5-methyl 4-(2,3-dichlorophenyl)-2-(hydroxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 1,4-Dihydropyridine-3,5-dicarboxylic acid, 4-(2,3-dichlorophenyl)-2-(hydroxymethyl)-3-(1-methylethyl)-6-methyl-, 3-methyl 5-(1-methylethyl) ester; Dihydropyridine derivative 98192-80-4; 2,3-Dichlorophenyl DHP intermediate; Hantzsch ester derivative.
EINECS	Contact for details

Quality Control

Our 3-Isopropyl 5-Methyl 4-(2,3-Dichlorophenyl)-2-(Hydroxymethyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.