Description

(6R,7R)-7-Amino-3-[(5-Methyl-2H-Tetrazol-2-Yl)Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Pivaloyloxymethyl Ester is a key pharmaceutical intermediate, specifically a prodrug ester derivative of a cephalosporin antibiotic. This compound is critical for enhancing the bioavailability and stability of active pharmaceutical ingredients (APIs) in final drug formulations. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the synthesis of advanced antibiotic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of third-generation cephalosporin antibiotics.
• Prodrug Synthesis: Used to create orally bioavailable prodrug forms of potent antibacterial agents, improving patient compliance.
• API Development: Serves as a precursor in research and development for new antimicrobial compounds targeting resistant pathogens.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for specialized pharmaceutical projects.
• Antibiotic Production: Integral to the industrial-scale production of specific broad-spectrum antibiotics.

Basic Information

Product Name	(6R,7R)-7-Amino-3-[(5-Methyl-2H-Tetrazol-2-Yl)Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Pivaloyloxymethyl Ester
CAS No.	98157-80-3
Molecular Formula	C18H26N6O5S
Molecular Weight	438.50 g/mol
Synonyms	Pivoxil Ester of Cephalosporin Intermediate; Cefpodoxime Proxetil Intermediate; 7-ACA Tetrazolyl POM Ester; (6R,7R)-7-Amino-3-(5-methyl-2H-tetrazol-2-yl)methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid pivaloyloxymethyl ester; Cefpodoxime Acid Pivaloyloxymethyl Ester; CETP-POM; 98157-80-3; Antibiotic Intermediate CE-80
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical methods including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R,7R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.