Description

(17α)-4-Bromo-17-Hydroxy-3-Oxo-19-Norpregna-4,9-Diene-21-Nitrile is a high-purity, advanced pharmaceutical intermediate of significant interest in synthetic organic chemistry. This compound is valued for its unique steroidal backbone, which serves as a critical building block in the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules, including potential hormone modulators and other specialized steroids.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates targeting hormonal pathways.
• Fine Chemical Synthesis: Serves as a versatile building block for constructing complex molecular architectures in custom synthesis and process development.
• Academic Research: Employed in university and institutional labs for studying organic reaction mechanisms and developing new synthetic methodologies involving steroidal frameworks.
• Biochemical Probe Development: Potential use in creating labeled compounds or probes for investigating steroid receptor interactions and biological pathways.

Basic Information

Item	Detail
Product Name	(17α)-4-Bromo-17-Hydroxy-3-Oxo-19-Norpregna-4,9-Diene-21-Nitrile
CAS No.	98149-13-4
Molecular Formula	C₂₁H₂₄BrNO₂
Molecular Weight	402.33 g/mol
Synonyms	4-Bromo-17α-hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 4-Bromo-17-hydroxy-3-oxo-19-norandrosta-4,9-diene-21-nitrile; 98149-13-4; 17α-Hydroxy-4-bromo-3-oxo-19-norpregna-4,9-diene-21-carbonitrile; 4-Bromo-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 21-nitrile
EINECS	Contact for details

Quality Control

Our (17α)-4-Bromo-17-Hydroxy-3-Oxo-19-Norpregna-4,9-Diene-21-Nitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.