Description

H-Glu(Otbu)-Obzl.Hcl is a protected amino acid derivative, specifically a benzyl ester of tert-butyloxycarbonyl-glutamic acid hydrochloride. This compound is a critical building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs), offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for advanced drug development and proteomics research.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• API Synthesis: Used in the manufacturing of Active Pharmaceutical Ingredients (APIs) that contain glutamic acid residues with specific side-chain protection.
• Bioconjugation: Serves as a reagent for modifying proteins, antibodies, or other biomolecules by introducing protected glutamic acid moieties.
• Research & Development: Employed in academic and industrial R&D for exploring new peptide-based drugs, diagnostics, and biochemical tools.
• Custom Peptide Production: A fundamental component for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	H-Glu(Otbu)-Obzl.Hcl
CAS No.	98102-32-0
Molecular Formula	C17H25NO5 • HCl
Molecular Weight	359.85 g/mol (Free base: 323.39)
Synonyms	H-Glu(OtBu)-OBzl hydrochloride; L-Glutamic acid, 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester, hydrochloride; Boc-Glu-OBzl HCl; N-(tert-Butoxycarbonyl)-L-glutamic acid 1-benzyl ester hydrochloride; γ-Benzyl N-Boc-L-glutamate hydrochloride; (S)-5-(tert-Butoxy)-4-((tert-butoxycarbonyl)amino)-5-oxopentanoic acid benzyl ester hydrochloride; Glutamic acid derivative 98102-32-0
EINECS	Contact for details

Quality Control

Our H-Glu(Otbu)-Obzl.Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.