Description

n-Boc Asp(Oh)Ome is a protected aspartic acid derivative, specifically the β-tert-butyl ester of aspartic acid α-methyl ester. This compound is a crucial building block in peptide synthesis, offering orthogonal protection strategies for the side-chain carboxylic acid group. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of aspartic acid with protected side-chain functionality.
• Solution-Phase Peptide Chemistry: Enables complex peptide coupling strategies in liquid-phase reactions.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide drugs and hormone analogs.
• Research & Development: Used in academic and industrial R&D for exploring new peptide structures and bio-conjugates.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective deprotection under mild acidic conditions, facilitating complex multi-step syntheses.

Basic Information

Product Name	n-Boc Asp(Oh)Ome
CAS No.	98045-03-5
Molecular Formula	C10H17NO6
Molecular Weight	247.25 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-aspartic acid β-tert-butyl ester α-methyl ester; (2S)-4-(tert-Butoxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid methyl ester; Boc-Asp(OtBu)-OMe; Boc-L-Asp(OtBu)-OMe; Methyl N-Boc-L-aspartate 4-tert-butyl ester; N-Boc-L-aspartic acid 4-tert-butyl 1-methyl ester; Aspartic acid, N-(1,1-dimethylethoxy)carbonyl]-, 1-methyl 4-(1,1-dimethylethyl) ester, (S)-
EINECS	Contact for details

Quality Control

Our n-Boc Asp(Oh)Ome is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality standards align with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.